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Article

Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40.

Current biology : CB - 2 Nov 2020

Salzberg Yehuda, Pechuk Vladyslava, Gat Asaf, Setty Hagar, Sela Sapir, Oren-Suissa Meital

Abstract excerpt

Sexually dimorphic circuits underlie behavioral differences between the sexes, yet the molecular mechanisms involved in their formation are poorly understood. We show here that sexually dimorphic connectivity patterns arise in C. elegans through local ubiquitin-mediated protein degradation in selected synapses of one sex but not the other. Specifically, synaptic degradation occurs via binding of the evolutionary...

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Identifiers

PMID: 32857970
DOI: 10.1016/j.cub.2020.08.002
PMCID: PMC7658809

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DCC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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