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Article

Presenilin-dependent receptor processing is required for axon guidance.

Cell - 7 Jan 2011

Bai Ge, Chivatakarn Onanong, Bonanomi Dario, Lettieri Karen, Franco Laura, Xia Caihong, Stein Elke, Ma Le, Lewcock Joseph W, Pfaff Samuel L

Abstract excerpt

The Alzheimer's disease-linked gene presenilin is required for intramembrane proteolysis of amyloid-β precursor protein, contributing to the pathogenesis of neurodegeneration that is characterized by loss of neuronal connections, but the role of Presenilin in establishing neuronal connections is less clear. Through a forward genetic screen in mice for recessive genes affecting motor neurons, we identified the...

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Source

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Identifiers

PMID: 21215373
DOI: 10.1016/j.cell.2010.11.053
PMCID: PMC3034090

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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