Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning.

doi:10.1523/JNEUROSCI.0677-08.2008

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Article

Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jun 2008

Hoopfer Eric D, Penton Andrea, Watts Ryan J, Luo Liqun

Abstract excerpt

Drosophila mushroom body (MB) gamma neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches. Developmental axon degeneration is initiated by the steroid hormone ecdysone, acting through a nuclear receptor complex composed of USP (ultraspiracle) and EcRB1 (ecdysone receptor B1) to regulate gene expression in MB gamma neurons. To identify...

Topics

Animals
Animals, Genetically Modified
Axons
CD8 Antigens
Drosophila
Drosophila Proteins
Ecdysone
Gene Expression Regulation, Developmental
Genomics
Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Larva

Microarray Analysis

Mushroom Bodies

Mutation

Neurons

RNA-Binding Proteins

Receptors, Steroid

Source

Open in PubMed Open full text

Identifiers

PMID: 18550751
DOI: 10.1523/JNEUROSCI.0677-08.2008
PMCID: PMC2713105

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