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Article

Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination.

Science (New York, N.Y.) - 17 Aug 2007

Ding Mei, Chao Dan, Wang George, Shen Kang

Abstract excerpt

Stereotyped synaptic connectivity can arise both by precise recognition between appropriate partners during synaptogenesis and by selective synapse elimination. The molecular mechanisms that underlie selective synapse removal are largely unknown. We found that stereotyped developmental elimination of synapses in the Caenorhabditis elegans hermaphrodite-specific motor neuron (HSNL) was mediated by an E3 ubiquitin...

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Identifiers

PMID: 17626846
DOI: 10.1126/science.1145727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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