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Genetic evolution of in situ follicular neoplasia to aggressive B-cell lymphoma of germinal center subtype

27 Aug 2020

Abstract excerpt

In situ follicular neoplasia (ISFN) is the earliest morphologically identifiable precursor of follicular lymphoma (FL). Although it is genetically less complex than FL and has low risk for progression, ISFN already harbors secondary genetic alterations, in addition to the defining t(14;18)(q32;q21) translocation. FL, in turn, frequently progresses to diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell...

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PMID: 32855278
DOI: 10.3324/haematol.2020.254854

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