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Article

Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue from a common precursor.

The Journal of pathology - 1 Sept 2023

Tzioni Maria-Myrsini, Wotherspoon Andrew, Chen Zi, Cucco Francesco, Makker Jasmine, Du Ming-Qing

Abstract excerpt

The translocation t(14;18)(q32:q21)/IGH::BCL2 occurs at the pre-B stage of B-cell development in the bone marrow and is insufficient for malignant transformation, although it leads to the formation of in situ follicular B-cell neoplasia (ISFN). Despite that, the translocation is the genetic hallmark of follicular lymphoma (FL), it occurs infrequently in metachronous/synchronous lymphomas, including extranodal...

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Topics

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Share to Lymphoma, B-Cell, Marginal Zone
Share to Lymphoma, Follicular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-bcl-2

Share to Translocation, Genetic

Source

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Identifiers

PMID: 37345526
DOI: 10.1002/path.6143
PMCID: PMC10952687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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