Article
Genomic and epigenomic co-evolution in follicular lymphomas.
Leukemia - 1 Feb 2015
Loeffler M, Kreuz M, Haake A, Hasenclever D, Trautmann H, Arnold C, Winter K, Koch K, Klapper W, Scholtysik R, Rosolowski M, Hoffmann S, Ammerpohl O, Szczepanowski M, Herrmann D, Küppers R, Pott C, Siebert R
Abstract excerpt
Follicular lymphoma (FL) with a t(14;18) is a B-cell neoplasm clinically characterized by multiple recurrencies. In order to investigate the clonal evolution of this lymphoma, we studied paired primary and relapse tumor samples from 33 patients with recurrent non-transformed t(14;18)-positive FL. We reconstructed phylogenetic trees of the evolution by taking advantage of the activation-induced cytidine deaminase...
Topics
- Adult
- Aged
- Aged, 80 and over
- Chromosomes
- Computational Biology
- Cytidine Deaminase
- DNA Methylation
- DNA Mutational Analysis
- Epigenesis, Genetic
- Epigenomics