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Article

Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.

Molecular cancer research : MCR - 1 Dec 2020

Song Shujie, Nguyen Vinh, Schrank Travis, Mulvaney Kathleen, Walter Vonn, Wei Darmood, Orvis Tess, Desai Nisarg, Zhang Jiren, Hayes D Neil, Zheng Yanfang, Major Michael B, Weissman Bernard E

Abstract excerpt

The NF-E2-related factor 2 (referred to as NRF2) transcription factor binds antioxidant responsive elements within the promoters of cytoprotective genes to induce their expression. Next-generation sequencing studies in lung cancer have shown a significant number of activating mutations within the NRF2 signaling pathway. Mutations in components of the SWI/SNF chromatin-remodeling complex, a general regulator of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32855269
DOI: 10.1158/1541-7786.MCR-20-0082
PMCID: PMC7718321

Genes

HMOX1
GCLM
NQO1
GSTM4
KEAP1
SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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