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Article

SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer.

Cell research - 1 Apr 2015

Papadakis Andreas I, Sun Chong, Knijnenburg Theo A, Xue Yibo, Grernrum Wipawadee, Hölzel Michael, Nijkamp Wouter, Wessels Lodewyk F A, Beijersbergen Roderick L, Bernards Rene, Huang Sidong

Abstract excerpt

Recurrent inactivating mutations in components of SWI/SNF chromatin-remodeling complexes have been identified across cancer types, supporting their roles as tumor suppressors in modulating oncogenic signaling pathways. We report here that SMARCE1 loss induces EGFR expression and confers resistance to MET and ALK inhibitors in non-small cell lung cancers (NSCLCs). We found that SMARCE1 binds to regulatory regions...

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Share to Anaplastic Lymphoma Kinase
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gefitinib

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Share to Proto-Oncogene Proteins c-met

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Source

Open in PubMed Open full text

Identifiers

PMID: 25656847
DOI: 10.1038/cr.2015.16
PMCID: PMC4387553

Genes

EGFR
SMARCE1
ALK
MET
CBX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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