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Targeting of BRM Sensitizes BRG1 -Mutant Lung Cancer Cell Lines to Radiotherapy

26 Nov 2018

Abstract excerpt

Abstract Targeting of epigenetic regulators as the chromatin remodeler SWI/SNF is proving to be a promising therapeutic strategy for individualized treatment of cancer patients. Here, we tested whether targeting one of the two mutually exclusive subdomains of the SWI/SNF complex BRM/SMARCA2 can sensitize specifically non–small cell lung carcinoma (NSCLC) cells with mutations in the other subunit BRG1/SMARCA4...

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PMID: 30478150
DOI: 10.1158/1535-7163.mct-18-0067

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Targeting of BRM Sensitizes BRG1 -Mutant Lung Cancer Cell Lines to RadiotherapyPMID 30478150Read ↗

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