Article
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines.
Human mutation - 1 May 2008
Medina Pedro P, Romero Octavio A, Kohno Takashi, Montuenga Luis M, Pio Ruben, Yokota Jun, Sanchez-Cespedes Montse
Abstract excerpt
Components of the SWI/SNF chromatin-remodeling complex, such as INI1, are inactivated in human cancer and, thus, act as tumor suppressors. Here we screened for mutations the entire coding sequence of BRG1 (SMARCA4), which encodes the ATPase of the complex, in 59 lung cancer cell lines of the most common histopathological types. Mutations were detected in 24% of the cancer cell lines, many of them in cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.