Article
Quantification, epitope mapping and genotype cross-reactivity of hepatitis B preS-specific antibodies in subjects vaccinated with different dosage regimens of BM32.
EBioMedicine - 1 Sept 2020
Tulaeva Inna, Cornelius Carolin, Zieglmayer Petra, Zieglmayer René, Schmutz René, Lemell Patrick, Weber Milena, Focke-Tejkl Margarete, Karaulov Alexander, Henning Rainer, Valenta Rudolf
Abstract excerpt
BACKGROUND: Chronic hepatitis B virus (HBV) infections are a global health problem. There is a need for therapeutic strategies blocking continuous infection of liver cells. The grass pollen allergy vaccine BM32 containing the preS domain of the large HBV surface protein (LHBs) as immunogenic carrier induced IgG antibodies in human subjects inhibiting HBV infection in vitro. Aim of this study was the...
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