Article
Immunogenicity of twenty peptides representing epitopes of the hepatitis B core and surface antigens by IFN-γ response in chronic and resolved HBV.
BMC immunology - 2 Nov 2015
Brinck-Jensen Nanna-Sophie, Vorup-Jensen Thomas, Leutscher Peter Derek Christian, Erikstrup Christian, Petersen Eskild
Abstract excerpt
BACKGROUND: Patients with chronic hepatitis B virus infection (CHB) usually mount a modest T cell response against HBV epitopes. In order to determine immunogenic epitopes of HBV recognized by HBV-specific T cells, previous studies focused on previously confirmed HBV epitopes and assessed the T cell response by the number of HBV-specific T cells by IFN-γ ELISPOT. METHODS: We studied T cell functionality by...
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