Article
Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2020
Uzawa Hirotsugu, Kohno Daisuke, Koga Tomoaki, Sasaki Tsutomu, Fukunaka Ayako, Okuno Toshiaki, Jo-Watanabe Airi, Kazuno Saiko, Miyatsuka Takeshi, Kitamura Tadahiro, Fujitani Yoshio, Watada Hirotaka, Saeki Kazuko, Yokomizo Takehiko
Abstract excerpt
Obesity is a health problem worldwide, and brown adipose tissue (BAT) is important for energy expenditure. Here, we explored the role of leukotriene A4 hydrolase (LTA4 H), a key enzyme in the synthesis of the lipid mediator leukotriene B4 (LTB4 ), in diet-induced obesity. LTA4 H-deficient (LTA4 H-KO) mice fed a high-fat diet (HFD) showed a lean phenotype, and bone-marrow transplantation studies revealed that LTA4...
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