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Article

Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype.

International journal of molecular sciences - 22 Aug 2020

Li Huifangjie, Knight William C, Yang Pengfei, Guo Yingqiu, Perlmutter Joel S, Morris John C, Bateman Randall J, Benzinger Tammie L S, Xu Jinbin

Abstract excerpt

We found interactions between dopamine and oxidative damage in the striatum involved in advanced neurodegeneration, which probably change the microglial phenotype. We observed possible microglia dystrophy in the striatum of neurodegenerative brains. To investigate the interactions between oxidative damage and microglial phenotype, we quantified myeloperoxidase (MPO), poly (ADP-Ribose) (PAR), and triggering...

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Identifiers

PMID: 32842621
DOI: 10.3390/ijms21176047
PMCID: PMC7503242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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