Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.

Scientific reports - 18 May 2016

Chen Juan-Juan, Gao Xiao-Tong, Yang Lan, Fu Wei, Liang Liang, Li Jun-Chang, Hu Bin, Sun Zhi-Jian, Huang Si-Yong, Zhang Yi-Zhe, Liang Ying-Min, Qin Hong-Yan, Han Hua

Abstract excerpt

Physical and chemical insult-induced bone marrow (BM) damage often leads to lethality resulting from the depletion of hematopoietic stem and progenitor cells (HSPCs) and/or a deteriorated BM stroma. Notch signaling plays an important role in hematopoiesis, but whether it is involved in BM damage remains unclear. In this study, we found that conditional disruption of RBP-J, the transcription factor of canonical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Cells
Share to Bone Marrow

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Binding Proteins

Share to Immunoglobulin J Recombination Signal Sequence-Binding Protein

Share to Intercellular Signaling Peptides and Proteins

Share to Myeloid Progenitor Cells

Share to Regeneration

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 27188577
DOI: 10.1038/srep26003
PMCID: PMC4870557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of Notch signaling aggravates irradiation-induced bone marrow injury, which is ameliorated by a soluble Dll1 ligand through Csf2rb2 upregulation.PMID 27188577Read ↗

Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndromeSemantic proximity Read ↗

Lifelong Residual bone Marrow Damage in Murine Survivors of the Hematopoietic Acute Radiation Syndrome (H-ARS): A Compilation of Studies Comprising the Indiana University ExperienceSemantic proximity Read ↗

Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice.Semantic proximity Read ↗

The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion.Semantic proximity Read ↗

Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function.Semantic proximity Read ↗

The bone marrow niche and hematopoietic system are distinctly remodeled by CD45-targeted astatine-211 radioimmunotherapySemantic proximity Read ↗

Non-Myelotoxic Agents as a Preparatory Regimen for Hematopoietic Stem Cell Gene TherapySemantic proximity Read ↗

Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice.Semantic proximity Read ↗

The Effects of Secondary Iron Overload and Iron Chelation on A Radiation-Induced Acute Myeloid Leukemia Mouse ModelSemantic proximity Read ↗

VEGF-C protects the integrity of the bone marrow perivascular niche in miceSemantic proximity Read ↗

Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axisSemantic proximity Read ↗

Diagnosis of Partial Body Radiation Exposure in Mice Using Peripheral Blood Gene Expression ProfilesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.