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Hematopoiesis and microenvironment in hematological malignancies

1 Sept 2018

Abstract excerpt

Adult hematopoietic stem cells (HSCs) and progenitors (HPCs) reside in the bone marrow, a highly orchestrated architecture. In the bone marrow, the process of how HSCs exert self-renewal and differentiation is tightly regulated by the surrounding microenvironment, or niche. Recent advances in imaging technologies and numerous knockout or knockin mouse models have greatly improved our understanding of the...

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PMID: 30671226
DOI: 10.1016/j.cr.2018.08.002

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