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Article

Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche.

Blood - 11 Aug 2011

Rehn Matilda, Olsson André, Reckzeh Kristian, Diffner Eva, Carmeliet Peter, Landberg Göran, Cammenga Jörg

Abstract excerpt

Hypoxia is emerging as an important characteristic of the hematopoietic stem cell (HSC) niche, but the molecular mechanisms contributing to quiescence, self-renewal, and survival remain elusive. Vascular endothelial growth factor A (VEGFA) is a key regulator of angiogenesis and hematopoiesis. Its expression is commonly regulated by hypoxia-inducible factors (HIF) that are functionally induced in low-oxygen...

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Identifiers

PMID: 21670467
DOI: 10.1182/blood-2011-01-332890

Genes

VEGFA

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