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Article

JAK2V617F-bearing vascular niche enhances malignant hematopoietic regeneration following radiation injury.

Haematologica - 1 Jul 2018

Lin Chi Hua Sarah, Zhang Yu, Kaushansky Kenneth, Zhan Huichun

Abstract excerpt

Myeloproliferative neoplasms are clonal stem cell disorders characterized by hematopoietic stem/progenitor cell expansion. The acquired kinase mutation JAK2V617F plays a central role in these disorders. Abnormalities of the marrow microenvironment are beginning to be recognized as an important factor in the development of myeloproliferative neoplasms. Endothelial cells are an essential component of the...

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Identifiers

PMID: 29567773
DOI: 10.3324/haematol.2017.185736
PMCID: PMC6029534

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