Article
A noncanonical role of NOD-like receptor NLRP14 in PGCLC differentiation and spermatogenesis.
Proceedings of the National Academy of Sciences of the United States of America - 8 Sept 2020
Yin Yike, Cao Shiyu, Fu Huancheng, Fan Xueying, Xiong Jingfei, Huang Qiuyue, Liu Yu, Xie Kun, Meng Tie-Gang, Liu Yuliang, Tang Dan, Yang Tingting, Dong Biao, Qi Shiqian, Nie Ling, Zhang Huiyuan, Hu Hongbo, Xu Wenming, Li Fuping, Dai Lunzhi, Sun Qing-Yuan, Li Zhonghan
Abstract excerpt
NOD-like receptors (NLRs) are traditionally recognized as major inflammasome components. The role of NLRs in germ cell differentiation and reproduction is not known. Here, we identified the gonad-specific Nlrp14 as a pivotal regulator in primordial germ cell-like cell (PGCLC) differentiation in vitro. Physiologically, knock out of Nlrp14 resulted in reproductive failure in both female and male mice. In adult male...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.