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Article

NLRP2 controls age-associated maternal fertility

23 Nov 2016

Abstract excerpt

Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are well-known for their key roles in the immune system. Ectopically expressed NLRP2 in immortalized cell lines assembles an inflammasome and inhibits activation of the proinflammatory transcription factor NF-κB, but the physiological roles of NLRP2 are unknown. Here, we show that Nlrp2-deficient mice were born with expected Mendelian ratios and...

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Identifiers

PMID: 27881734
DOI: 10.1084/jem.20160900

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