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Article

Diffuse midline glioma with novel, potentially targetable, FGFR2-VPS35 fusion.

Cold Spring Harbor molecular case studies - 1 Oct 2020

Zanazzi George, Liechty Benjamin L, Pendrick Danielle, Krasnozhen-Ratush Olga, Snuderl Matija, Allen Jeffrey C, Garvin James H, Mansukhani Mahesh M, Roth Kevin A, Hsiao Susan J

Abstract excerpt

We report a case of a slow-growing, diffuse, infiltrating glioma in the right brainstem of a 9-yr-old boy. The tumor was negative by immunohistochemical staining for histone H3 K27M, BRAF V600E, and IDH1 R132H mutations. Fluorescence in situ hybridization did not reveal a BRAF duplication. Genomic profiling of the tumor, by DNA methylation array and cancer whole-exome and transcriptome sequencing, was performed....

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Identifiers

PMID: 32839179
DOI: 10.1101/mcs.a005660
PMCID: PMC7552930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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