Article
Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation.
Journal of neuro-oncology - 1 Jun 2016
Dodgshun Andrew J, SantaCruz Nadine, Hwang Jaeho, Ramkissoon Shakti H, Malkin Hayley, Bergthold Guillaume, Manley Peter, Chi Susan, MacGregor Duncan, Goumnerova Liliana, Sullivan Michael, Ligon Keith, Beroukhim Rameen, Herrington Betty, Kieran Mark W, Hansford Jordan R, Bandopadhayay Pratiti
Abstract excerpt
Disseminated glioneuronal tumors of childhood are rare. We present a retrospective IRB-approved review of the clinical course and frequency of BRAF mutations in disseminated glioneuronal tumors at two institutions. Defining features of our cohort include diffuse leptomeningeal-spread, often with a discrete spinal cord nodule and oligodendroglioma-like histologic features. Patients were identified through a...
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