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Article

From Molecular Alterations to the Targeted Therapy: Treatment of Thalamic Glioma in Pediatric Patients.

International journal of molecular sciences - 9 Jan 2026

Yilmaz Yasin

Abstract excerpt

Thalamic gliomas are among the most challenging pediatric brain tumors due to the delicate functions of the thalamus. Limited surgical intervention leads to the use of adjuvant therapies, including targeted therapy. Thalamic gliomas can be divided into two distinct groups: diffuse midline glioma (DMG) and low-grade glioma (LGG). The most common mutations that can be targeted for treatment are the KIAA1549-BRAF...

Topics

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Brain Neoplasms
Child
BRAF gene
CDK4 gene
Glioma
Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 41596345
DOI: 10.3390/ijms27020695
PMCID: PMC12840966

Genes

BRAF
EGFR
CDK4
KIAA1549

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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