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Article

The auxiliary subunit KCNE1 regulates KCNQ1 channel response to sustained calcium-dependent PKC activation.

PloS one - 1 Jan 2020

Xu Parks Xiaorong, Qudsi Haani, Braun Chen, Lopes Coeli M B

Abstract excerpt

The slow cardiac delayed rectifier current (IKs) is formed by KCNQ1 and KCNE1 subunits and is one of the major repolarizing currents in the heart. Decrease of IKs currents either due to inherited mutations or pathological remodeling is associated with increased risk for cardiac arrhythmias and sudden death. Ca2+-dependent PKC isoforms (cPKC) are chronically activated in heart disease and diabetes. Recently, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myocytes, Cardiac

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Source

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Identifiers

PMID: 32833978
DOI: 10.1371/journal.pone.0237591
PMCID: PMC7446858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The auxiliary subunit KCNE1 regulates KCNQ1 channel response to sustained calcium-dependent PKC activation.PMID 32833978Read ↗

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KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders.Semantic proximity Read ↗

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Mutation in KCNE1 associated to early repolarization syndrome by modulation of slowly activating delayed rectifier K+ current.Semantic proximity Read ↗

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