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Article

Unspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis.

Frontiers in immunology - 1 Jan 2024

Zaied Roan E, Gokuladhas Sreemol, Walker Caroline, O'Sullivan Justin M

Abstract excerpt

Introduction: Asthma is a heterogeneous condition that is characterized by reversible airway obstruction. Childhood-onset asthma (COA) and adult-onset asthma (AOA) are two prominent asthma subtypes, each with unique etiological factors and prognosis, which suggests the existence of both shared and distinct risk factors. Methods: Here, we employed a two-sample Mendelian randomization analysis to elucidate the...

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Age of Onset
Asthma
Gene Regulatory Networks
Genome-Wide Association Study
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Quantitative Trait Loci

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PMID: 39628479
DOI: 10.3389/fimmu.2024.1412032
PMCID: PMC11611866

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