Article
Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease.
The Journal of allergy and clinical immunology - 1 Mar 2014
Poole Alex, Urbanek Cydney, Eng Celeste, Schageman Jeoffrey, Jacobson Sean, O'Connor Brian P, Galanter Joshua M, Gignoux Christopher R, Roth Lindsey A, Kumar Rajesh, Lutz Sharon, Liu Andrew H, Fingerlin Tasha E, Setterquist Robert A, Burchard Esteban G, Rodriguez-Santana Jose, Seibold Max A
Abstract excerpt
BACKGROUND: Bronchial airway expression profiling has identified inflammatory subphenotypes of asthma, but the invasiveness of this technique has limited its application to childhood asthma. OBJECTIVES: We sought to determine whether the nasal transcriptome can proxy expression changes in the lung airway transcriptome in asthmatic patients. We also sought to determine whether the nasal transcriptome can...
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