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Article

Genetic and epigenetic alterations of myeloproliferative disorders.

International journal of hematology - 1 Feb 2013

Milosevic Jelena D, Kralovics Robert

Abstract excerpt

The classical BCR-ABL negative myeloproliferative neoplasms (MPN) polycythemia vera, essential thrombocythemia, and primary myelofibrosis are clonal hematopoietic disorders characterized by excessive production of terminally differentiated myeloid cells. In MPN patients, the disease can progress to secondary myelofibrosis or acute myeloid leukemia. Clonal hematopoiesis, disease phenotype, and progression are...

Topics

Adaptor Proteins, Signal Transducing
Chromosome Aberrations
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A
DNA-Binding Proteins
Dioxygenases
Disease Progression
Epigenesis, Genetic
Humans
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

Janus Kinase 2

Mutation

Myeloproliferative Disorders

Polycomb Repressive Complex 2

Proteins

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-cbl

Source

Identifiers

PMID: 23233154
DOI: 10.1007/s12185-012-1235-2

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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