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Article

Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: are we there yet?

Seminars in oncology - 1 Apr 2011

Odenike Olatoyosi, Thirman Michael J, Artz Andrew S, Godley Lucy A, Larson Richard A, Stock Wendy

Abstract excerpt

Myeloid neoplasms are characterized by acquired somatic mutations and epigenetic alterations in genes that are crucial for hematopoietic differentiation and cellular proliferation and survival pathways. The heterogeneity and genetic complexity of these disorders is daunting, but the improvement in our knowledge of the pathogenetic mechanisms underlying myeloid transformation, coupled with the increasing...

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PMID: 21421110
DOI: 10.1053/j.seminoncol.2011.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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