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Article

Molecular pathogenesis of the myeloproliferative neoplasms.

Journal of hematology & oncology - 30 Jun 2021

Greenfield Graeme, McMullin Mary Frances, Mills Ken

Abstract excerpt

The Philadelphia negative myeloproliferative neoplasms (MPN) compromise a heterogeneous group of clonal myeloid stem cell disorders comprising polycythaemia vera, essential thrombocythaemia and primary myelofibrosis. Despite distinct clinical entities, these disorders are linked by morphological similarities and propensity to thrombotic complications and leukaemic transformation. Current therapeutic options are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34193229
DOI: 10.1186/s13045-021-01116-z
PMCID: PMC8246678

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