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Integrative analysis of scRNA-seq and GWAS data pinpoints periportal hepatocytes as the relevant liver cell types for blood lipids.

Human molecular genetics - 4 Nov 2020

Hao Xingjie, Wang Kai, Dai Chengguqiu, Ding Zeyang, Yang Wei, Wang Chaolong, Cheng Shanshan

Abstract excerpt

Liver, a heterogeneous tissue consisting of various cell types, is known to be relevant for blood lipid traits. By integrating summary statistics from genome-wide association studies (GWAS) of lipid traits and single-cell transcriptome data of the liver, we sought to identify specific cell types in the liver that were most relevant for blood lipid levels. We conducted differential expression analyses for 40 cell...

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PMID: 32821946
DOI: 10.1093/hmg/ddaa188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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