Article

Single-cell RNA sequencing identifies the specific cell types of GWAS genes associated with liver disease

2019-10-04

Abstract excerpt

<title>Abstract</title> <p>Background The liver is an important digestive organ in the human body, which has a variety of physiological functions. Once the liver occurs dysfunction, it may indicate the occurrence of liver disease. Genome-wide association studies (GWAS) have identified a lot of genetic variants which are associated with liver disease. However, it is not clear that the genes with variants in which...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71905193-599e-5f3e-8a33-2fabbd542a43
DOI: 10.21203/rs.2.15630/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell RNA sequencing identifies the specific cell types of GWAS genes associated with liver diseaseDOI 10.21203/rs.2.15630/v1Read

Single-cell transcriptomics reveals the impact of sex and age in the healthy human liverSemantic proximity Read

Single-Cell Transcriptomic Landscape of Intrahepatic B Cells in NASHSemantic proximity Read

A Single Cell Gene Expression Atlas of 28 Human LiversSemantic proximity Read

Integrative analysis of scRNA-seq and GWAS data pinpoints periportal hepatocytes as the relevant liver cell types for blood lipids.Semantic proximity Read

Single-Cell Transcriptome Analysis Identifies Novel Biomarkers Involved in Major Liver Cancer SubtypesSemantic proximity Read

A Human Liver Cell Atlas: Revealing Cell Type Heterogeneity and Adult Liver Progenitors by Single-Cell RNA-sequencingSemantic proximity Read

Decoding liver fibrogenesis with single-cell technologiesSemantic proximity Read

Single-cell RNA sequencing advances in revealing the development and progression of MASH: the identifications and interactions of non-parenchymal cellsSemantic proximity Read

Transcriptome analysis of liver sinusoidal endothelial cells in patients with liver cirrhosisSemantic proximity Read

Integrated analysis of single-cell transcriptome of liver cancer and cirrhosis reveals cell lineage similarity and prognostic-associated subpopulationsSemantic proximity Read

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosisSemantic proximity Read

Single cell sequencing and multiple machine learning identified CD2 and ITGAV as novel biomarkers for NASH-related fibrosisSemantic proximity Read