Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Gain-of-Function KCND3 Variant Associated with Brugada Syndrome.

Cardiology - 1 Jan 2020

Li Xianqing, Li Zongzhe, Wang Dao Wen Wen, Wang Dao Wu, Wang Yan

Abstract excerpt

Brugada syndrome (BrS) is a known cause of sudden cardiac death (SCD) characterized by abnormal electrocardiograms and fatal arrhythmias. The variants in KCND3 encoding the KV4.3 potassium-channel (the α-subunit of the Ito) have seldom been reported in BrS. This study aimed to identify novel KCND3 variants associated with BrS and elucidate BrS pathogenesis. High-depth targeted sequencing was performed and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Patch-Clamp Techniques
Share to Brugada Syndrome
Share to Death, Sudden, Cardiac

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Source

Identifiers

PMID: 32818936
DOI: 10.1159/000508033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Gain-of-Function KCND3 Variant Associated with Brugada Syndrome.PMID 32818936Read ↗

Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome.Semantic proximity Read ↗

KCNE3 T4A as the genetic basis of Brugada-pattern electrocardiogram.Semantic proximity Read ↗

Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome.Semantic proximity Read ↗

GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death.Semantic proximity Read ↗

The genetic basis of Brugada syndrome: a mutation update.Semantic proximity Read ↗

Unravelling Novel SCN5A Mutations Linked to Brugada Syndrome: Functional, Structural, and Genetic Insights.Semantic proximity Read ↗

Novel Gain-of-Function Mutation in the Kv11.1 Channel Found in the Patient with Brugada Syndrome and Mild QTc ShorteningSemantic proximity Read ↗

Caveolin 3 Variant T78M in a Large Family With Brugada Syndrome: Clinical Features and Coexistence of ADRB1 and GRK5 Gene Mutation.Semantic proximity Read ↗

Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function.Semantic proximity Read ↗

Gain-of-function KCNH2 mutations in patients with Brugada syndrome.Semantic proximity Read ↗

Genetic and clinical aspects of Brugada syndrome: an update.Semantic proximity Read ↗

A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.