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Article

A Novel Gain-of-Function KCND3 Variant Associated with Brugada Syndrome.

Cardiology - 1 Jan 2020

Li Xianqing, Li Zongzhe, Wang Dao Wen Wen, Wang Dao Wu, Wang Yan

Abstract excerpt

Brugada syndrome (BrS) is a known cause of sudden cardiac death (SCD) characterized by abnormal electrocardiograms and fatal arrhythmias. The variants in KCND3 encoding the KV4.3 potassium-channel (the α-subunit of the Ito) have seldom been reported in BrS. This study aimed to identify novel KCND...

Topics

Brugada Syndrome
Death, Sudden, Cardiac
Gain of Function Mutation
Humans
Mutation
Patch-Clamp Techniques
Shal Potassium Channels

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32818936
DOI: 10.1159/000508033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-32818936-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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