Article
GSTM3 variant is a novel genetic modifier in Brugada syndrome, a disease with risk of sudden cardiac death.
EBioMedicine - 1 Jul 2020
Juang Jyh-Ming Jimmy, Binda Anna, Lee Shyh-Jye, Hwang Juey-Jen, Chen Wen-Jone, Liu Yen-Bin, Lin Lian-Yu, Yu Chih-Chieh, Ho Li-Ting, Huang Hui-Chun, Chen Ching-Yu Julius, Lu Tzu-Pin, Lai Liang-Chuan, Yeh Shih-Fan Sherri, Lai Ling-Ping, Chuang Eric Y, Rivolta Ilaria, Antzelevitch Charles
Abstract excerpt
BACKGROUND: Brugada syndrome (BrS) is a rare inherited disease causing sudden cardiac death (SCD). Copy number variants (CNVs) can contribute to disease susceptibility, but their role in Brugada syndrome (BrS) is unknown. We aimed to identify a CNV associated with BrS and elucidated its clinical implications. METHODS: We enrolled 335 unrelated BrS patients from 2000 to 2018 in the Taiwanese population. Microarray...
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