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Article

Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome.

Circulation. Arrhythmia and electrophysiology - 1 Aug 2008

Delpón Eva, Cordeiro Jonathan M, Núñez Lucía, Thomsen Poul Erik Bloch, Guerchicoff Alejandra, Pollevick Guido D, Wu Yuesheng, Kanters Jørgen K, Larsen Carsten Toftager, Hofman-Bang Jacob, Burashnikov Elena, Christiansen Michael, Antzelevitch Charles

Abstract excerpt

INTRODUCTION: The Brugada Syndrome (BrS), an inherited syndrome associated with a high incidence of sudden cardiac arrest, has been linked to mutations in four different genes leading to a loss of function in sodium and calcium channel activity. Although the transient outward current (I(to)) is thought to play a prominent role in the expression of the syndrome, mutations in I(to)-related genes have not been...

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Identifiers

PMID: 19122847
DOI: 10.1161/CIRCEP.107.748103
PMCID: PMC2585750

Genes

KCND3
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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