Article
Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome.
Circulation. Arrhythmia and electrophysiology - 1 Aug 2008
Delpón Eva, Cordeiro Jonathan M, Núñez Lucía, Thomsen Poul Erik Bloch, Guerchicoff Alejandra, Pollevick Guido D, Wu Yuesheng, Kanters Jørgen K, Larsen Carsten Toftager, Hofman-Bang Jacob, Burashnikov Elena, Christiansen Michael, Antzelevitch Charles
Abstract excerpt
INTRODUCTION: The Brugada Syndrome (BrS), an inherited syndrome associated with a high incidence of sudden cardiac arrest, has been linked to mutations in four different genes leading to a loss of function in sodium and calcium channel activity. Although the transient outward current (I(to)) is t...
Topics
- Action Potentials
- Adolescent
- Adult
- Aged
- Brugada Syndrome
- Cells, Cultured
- Child
- DNA
- DNA Mutational Analysis
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Humans
- Immunoprecipitation