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Article

Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function.

International journal of molecular medicine - 1 Jul 2015

You Tao, Mao Weike, Cai Benzhi, Li Faqian, Xu Haodong

Abstract excerpt

The human cardiac fast transient outward K+ channel is composed of the KV4.3 α subunit encoded by KCND3 and the K+ channel‑interacting protein 2 (KChIP2) β subunit, and determines the early repolarization of the action potential (AP). Two human mutations (G600R and L450F) in KV4.3 are associated with Brugada syndrome and they increase the KV4.3/KChIP2‑encoded fast transient outward K+ current (Ito,f) and cause...

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Identifiers

PMID: 26016905
DOI: 10.3892/ijmm.2015.2223
PMCID: PMC4494594

Genes

KCND3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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