Article
Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function.
International journal of molecular medicine - 1 Jul 2015
You Tao, Mao Weike, Cai Benzhi, Li Faqian, Xu Haodong
Abstract excerpt
The human cardiac fast transient outward K+ channel is composed of the KV4.3 α subunit encoded by KCND3 and the K+ channel‑interacting protein 2 (KChIP2) β subunit, and determines the early repolarization of the action potential (AP). Two human mutations (G600R and L450F) in KV4.3 are associated...
Topics
- Brugada Syndrome
- Cell Line
- Cell Membrane
- HEK293 Cells
- Heart
- Humans
- Kv Channel-Interacting Proteins
- Membrane Potentials
- Mutation
- Myocardium
- Patch-Clamp Techniques
- RNA, Messenger
- Shal Potassium Channels