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Article

Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome.

Heart rhythm - 1 Jul 2011

Giudicessi John R, Ye Dan, Tester David J, Crotti Lia, Mugione Alessandra, Nesterenko Vladislav V, Albertson Richard M, Antzelevitch Charles, Schwartz Peter J, Ackerman Michael J

Abstract excerpt

BACKGROUND: Brugada syndrome (BrS) is a sudden death-predisposing genetic condition characterized electrocardiographically by ST segment elevation in the leads V(1)-V(3). Given the prominent role of the transient outward current (I(to)) in BrS pathogenesis, we hypothesized that rare gain-of-function mutations in KCND3 may serve as a pathogenic substrate for BrS. METHODS: Comprehensive mutational analysis of...

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Identifiers

PMID: 21349352
DOI: 10.1016/j.hrthm.2011.02.021
PMCID: PMC3150551

Genes

KCND3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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