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Article

Causal Associations of Sleep Apnea With Alzheimer Disease and Cardiovascular Disease: A Bidirectional Mendelian Randomization Analysis.

Journal of the American Heart Association - 17 Sept 2024

Cavaillès Clémence, Andrews Shea J, Leng Yue, Chatterjee Aadrita, Daghlas Iyas, Yaffe Kristine

Abstract excerpt

BACKGROUND: Sleep apnea (SA) has been linked to an increased risk of dementia in numerous observational studies; whether this is driven by neurodegenerative, vascular, or other mechanisms is not clear. We sought to examine the bidirectional causal relationships between SA, Alzheimer disease (AD), coronary artery disease (CAD), and ischemic stroke using Mendelian randomization. METHODS AND RESULTS: Using summary...

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Identifiers

PMID: 39258525
DOI: 10.1161/JAHA.123.033850
PMCID: PMC11935638

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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