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Article

Sleep and dementia: Assessing established dementia-related factors using multivariable Mendelian randomization.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2026

Guo Yunyun, Wang Rui, Sindi Shireen, Middleton Lefkos T, Kivipelto Miia

Abstract excerpt

INTRODUCTION: The relationship between sleep, other dementia risk factors, and dementia remains unclear. We aim to explore these associations using a two-sample Mendelian randomization (MR) approach. METHODS: We identified genetic instrumental variables for sleep characteristics from the UK Biobank and obtained summary-level genetic association data for dementia outcomes, including Alzheimer's disease (AD), from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42298291
DOI: 10.1002/alz.71592
PMCID: PMC13269015

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