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Article

Rapid eye movement sleep behavior disorder (RBD) and neurodegenerative diseases: A bidirectional 2-sample Mendelian randomization study.

Medicine - 3 Oct 2025

Hu Wei, Liu Xin, Zhang Peng

Abstract excerpt

Observational studies have documented association between rapid eye movement sleep behavior disorder (RBD) and neurodegenerative diseases, but the causal relationship remains to be established. In this study, we utilized a bidirectional 2-sample Mendelian randomization (MR) approach to assess the potential causal connection between RBD and 6 neurodegenerative conditions, including Alzheimer disease (AD),...

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Identifiers

PMID: 41054101
DOI: 10.1097/MD.0000000000044816
PMCID: PMC12499814

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