Article
Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Mar 2015
Maruyama Hidekazu, Dewachter Céline, Belhaj Asmae, Rondelet Benoit, Sakai Satoshi, Remmelink Myriam, Vachiery Jean-Luc, Naeije Robert, Dewachter Laurence
Abstract excerpt
BACKGROUND: Endothelin receptor antagonists improve pulmonary arterial hypertension (PAH). Mutations in the bone morphogenetic protein (BMP) type 2 receptor (BMPR2) predispose to PAH. Here, we sought to determine whether there might exist interactions between these 2 signaling pathways and their effect on the acquisition of the altered phenotype of pulmonary artery smooth muscle cells (PA-SMCs) observed in PAH....
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