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Article

Causal relationship between neuroticism and bone mineral density: A univariable and multivariable Mendelian randomization study.

Medicine - 13 Sept 2024

Chen Shangtong, Zhong Jing, Chen Yueping, Zhang Xiaoyun, Huang Chuanhong, Chen Feng

Abstract excerpt

Recent observational studies have indicated that psychiatric disorders were associated with risk of bone mineral density (BMD) reduction. But the causal relationship between neuroticism and BMD remained unclear. By using public genome-wide association study data, a 2-sample bidirectional Mendelian randomization (MR) study was performed to investigate the causal relationship between neuroticism and BMD (heel BMD,...

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Bone Density
Genome-Wide Association Study
Mendelian Randomization Analysis
Neuroticism
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39287255
DOI: 10.1097/MD.0000000000039706
PMCID: PMC11404915

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