Article
Estimating the heritability of reporting stressful life events captured by common genetic variants.
Psychological medicine - 1 Sept 2013
Power R A, Wingenbach T, Cohen-Woods S, Uher R, Ng M Y, Butler A W, Ising M, Craddock N, Owen M J, Korszun A, Jones L, Jones I, Gill M, Rice J P, Maier W, Zobel A, Mors O, Placentino A, Rietschel M, Lucae S, Holsboer F, Binder E B, Keers R, Tozzi F, Muglia P, Breen G, Craig I W, Müller-Myhsok B, Kennedy J L, Strauss J, Vincent J B, Lewis C M, Farmer A E, McGuffin P
Abstract excerpt
BACKGROUND: Although usually thought of as external environmental stressors, a significant heritable component has been reported for measures of stressful life events (SLEs) in twin studies. Method We examined the variance in SLEs captured by common genetic variants from a genome-wide association study (GWAS) of 2578 individuals. Genome-wide complex trait analysis (GCTA) was used to estimate the phenotypic...
Topics
- Anxiety Disorders
- Gene-Environment Interaction
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Life Change Events
- Models, Genetic
- Neuroticism