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Mitochondrial DNA Manipulations Affect Tau Oligomerization

11 Aug 2020

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction and tau aggregation occur in Alzheimer's disease (AD), and exposing cells or rodents to mitochondrial toxins alters their tau. OBJECTIVE: To further explore how mitochondria influence tau, we measured tau oligomer levels in human neuronal SH-SY5Y cells with different mitochondrial DNA (mtDNA) manipulations. METHODS: Specifically, we analyzed cells undergoing ethidium...

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PMID: 32804126
DOI: 10.3233/jad-200286

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