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Article

Increased expression of ApoE and protection from amyloid-beta toxicity in transmitochondrial cybrids with haplogroup K mtDNA.

Neurobiology of disease - 1 Sept 2016

Thaker Kunal, Chwa Marilyn, Atilano Shari R, Coskun Pinar, Cáceres-Del-Carpio Javier, Udar Nitin, Boyer David S, Jazwinski S Michal, Miceli Michael V, Nesburn Anthony B, Kuppermann Baruch D, Kenney M Cristina

Abstract excerpt

Mitochondrial (mt) DNA haplogroups, defined by specific single nucleotide polymorphism (SNP) patterns, represent populations of diverse geographic origins and have been associated with increased risk or protection of many diseases. The H haplogroup is the most common European haplogroup while the K haplogroup is highly associated with the Ashkenazi Jewish population. Transmitochondrial cybrids (cell lines with...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27109188
DOI: 10.1016/j.nbd.2016.04.005
PMCID: PMC5922440

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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