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Article

Inhibiting mtDNA transcript translation alters Alzheimer's disease‐associated biology

23 Oct 2024

Abstract excerpt

INTRODUCTION: Alzheimer's disease (AD) features changes in mitochondrial structure and function. Investigators debate where to position mitochondrial pathology within the chronology and context of other AD features. METHODS: To address whether mitochondrial dysfunction alters AD-implicated genes and proteins, we treated SH-SY5Y cells and induced pluripotent stem cell (iPSC)-derived neurons with chloramphenicol,...

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Share to Alzheimer's disease research and treatments
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PMID: 39441557
DOI: 10.1002/alz.14275

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