Article
Mitochondria in sporadic amyotrophic lateral sclerosis.
Experimental neurology - 1 Sept 1998
Swerdlow R H, Parks J K, Cassarino D S, Trimmer P A, Miller S W, Maguire D J, Sheehan J P, Maguire R S, Pattee G, Juel V C, Phillips L H, Tuttle J B, Bennett J P, Davis R E, Parker W D
Abstract excerpt
Mitochondria are abnormal in persons with amyotrophic lateral sclerosis (ALS) for unknown reasons. We explored whether aberration of mitochondrial DNA (mtDNA) could play a role in this by transferring mitochondrial DNA (mtDNA) from ALS subjects to mtDNA-depleted human neuroblastoma cells. Resulting ALS cytoplasmic hybrids (cybrids) exhibited abnormal electron transport chain functioning, increases in free radical...
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