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Article

Using collections of structural models to predict changes of binding affinity caused by mutations in protein-protein interactions.

Protein science : a publication of the Protein Society - 1 Oct 2020

Meseguer Alberto, Dominguez Lluis, Bota Patricia M, Aguirre-Plans Joaquim, Bonet Jaume, Fernandez-Fuentes Narcis, Oliva Baldo

Abstract excerpt

Protein-protein interactions (PPIs) in all the molecular aspects that take place both inside and outside cells. However, determining experimentally the structure and affinity of PPIs is expensive and time consuming. Therefore, the development of computational tools, as a complement to experimental methods, is fundamental. Here, we present a computational suite: MODPIN, to model and predict the changes of binding...

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Identifiers

PMID: 32797645
DOI: 10.1002/pro.3930
PMCID: PMC7513729

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