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Article

A computational model of induced pluripotent stem-cell derived cardiomyocytes for high throughput risk stratification of KCNQ1 genetic variants.

PLoS computational biology - 1 Aug 2020

Kernik Divya C, Yang Pei-Chi, Kurokawa Junko, Wu Joseph C, Clancy Colleen E

Abstract excerpt

In the last decade, there has been tremendous progress in identifying genetic anomalies linked to clinical disease. New experimental platforms have connected genetic variants to mechanisms underlying disruption of cellular and organ behavior and the emergence of proarrhythmic cardiac phenotypes. The development of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) signifies an important advance in...

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Identifiers

PMID: 32797034
DOI: 10.1371/journal.pcbi.1008109
PMCID: PMC7449496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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