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Article

iPSC-Based Modeling of Variable Clinical Presentation in Hypertrophic Cardiomyopathy.

Circulation research - 7 Jul 2023

Escribá Rubén, Larrañaga-Moreira José M, Richaud-Patin Yvonne, Pourchet Léa, Lazis Ioannis, Jiménez-Delgado Senda, Morillas-García Alba, Ortiz-Genga Martín, Ochoa Juan Pablo, Carreras David, Pérez Guillermo Javier, de la Pompa José Luis, Brugada Ramón, Monserrat Lorenzo, Barriales-Villa Roberto, Raya Angel

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and a frequent cause of heart failure and sudden cardiac death. Our understanding of the genetic bases and pathogenic mechanisms underlying HCM has improved significantly in the recent past, but the combined effect of various pathogenic gene variants and the influence of genetic modifiers in disease manifestation are very...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37317833
DOI: 10.1161/CIRCRESAHA.122.321951

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